FIRST TRIMESTER

THE FIRST SYMPTOMS OF PREGNANCY

When you miss your mensis, it is the main sign of a pregnancy. However, women with irregular menstruation, at the beginning, might not find out about pregnancy with this bell. During this period, ladies feel a need to urinate very often, strong weakness, nausea and/or vomiting, and increased breast tenderness. Of course, these symptoms can be natural. Most over-the-counter pregnancy tests are sensitive 9-12 days after conception, and they are reachable at many chemistries. Doing these tests, helps to emit disorientation and guesswork. A serum pregnancy test (done at clinic or laboratory) may show pregnancy in 8-11 days after conception.

The period necessarry for IMPLANTation of fertilized egg

The fertilized egg gets in the uterus as a 2- to 8-cell embryo and navigates in the endometrial cavity about 90-150 hours in 4-7 days after conception. Most embryos implant by the morula stage, when the embryo contains many cells. It occurs, almost, 6 days after conception. Then, the new embryo provides the lining changes of the endometrium, which is named decidualization. It quickly starts to develop the physiologic changes that form maternal-placental exchange. Up to this period, medicine, which woman takes, don’t influence on a pregnancy.

THE best TEST for PREGNANCY detection 

Serum beta–human chorionic gonadotropin (hCG) is the hormone secreted by the syncytiotrophoblast on the first day of implantation, and it grows fast in both the maternal blood stream and the maternal urine. The serum hCG test is the most sensitive and particular, and the hormone can be determined in blood and urine approximately in 8-9 days after conception. This test can be done quantitatively or qualitatively. Urine pregnancy tests vary in their sensitivity and specificity, which are based on the hCG units set as the cutoff for a positive test result, usually 2-5 mIU/mL.

Urine pregnancy tests can show positive results at the level of 20 mIU/mL, which is 2-3 days before ladies wait the next mensis. The kits are definite and available. The test can be finished in about 3-5 minutes. The all kits utilize the same method—identification by an antibody of the beta subunit of hCG. False results of the hCG hormone can happen in cases of hydatidiform molar pregnancy or other placental abnormalities. Besides, test results can be positive for pregnancy weeks after a pregnancy termination, miscarriage, or child birth. However, false-negative test results can happen from incorrect test preparation, urine that is too dilute, or intervention of some pills.

Serum pregnancy tests can be provided by a lot of techniques. The enzyme-linked immunosorbent assay (ELISA) is used the most at many labs. This test is a detection of total beta-hCG levels. It is done using a monoclonal antibody to bind to the hCG; a second antibody is added that collaborates with hCG and expends color while performing such an action. This model of ELISA is generally named a “sandwich” of the sample hCG. Radioimmunoassay (RIA) is still used by several labs. This test adds radiolabeled anti-hCG antibody to nonlabeled hCG of the blood sample. The count is then principally detects by the expanse of dislocation of the radiolabeled sample.

The hCG level doubles almost every 2 days in early pregnancy. Besides, it must be indicated that even boosts for only 33% can be persistent with healthy pregnancies. These standards raise up 60-70 days and then cutback to very low levels up to 100-130 days and never reduce until the pregnancy is finished.

CRAMPING DURING PREGNANCY

On the first period of pregnancy, uterine cramping can show natural changes of pregnancy initiated by hormonal changes; later in pregnancy, it may signify an enlarging uterus. Cramping that varies from previous pregnancies, worsening cramping, or cramping related with any vaginal bleeding can be a signal of ectopic pregnancy, threatened abortion, or missed abortion.

Other physical effects that are normal during pregnancy, and not obligatory signs of illness, including nausea, vomiting, increase in abdominal girth, changes in bowel habits, increased urinary frequency, palpitations or more rapid heartbeat, upheaving of the chest (especially with breathing), heart murmurs, swelling of the ankles, and shortness of breath.

The reason of fatigue during pregnancy

Fatigue in early pregnancy is natural. Lot of changes are happening as the new pregnancy happens, and ladies feel it as weakness and a big desire to have a nap. Lower blood pressure level, lower blood sugar levels, hormonal changes due to the soporific effects of progesterone, metabolic changes, and the physiologic anemia of pregnancy lead to fatigue. Women must examine with their gynecologist to detect  if an additional training, prenatal vitamin changes, and/or supplemental iron can be helpful.

 

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